Key Publications

1. Management of Endocrine Disease: Hypoparathyroidism in pregnancy: review and evidence-based recommendations for management. Khan AA, Clarke B, Rejnmark L, Brandi ML European Journal of Endocrinology 2019 Feb 1;180(2):R37-R44. doi: 10.1530/EJE-18-0541.
2. Standards of Care for Hypoparathyroidism in Adults. Khan AA, Koch C, Van Uum SHM, Baillargeon JP, Bollerslev J, Brandi ML, Marcocci C, Rejnmark L, Rizzoli R, Shrayyef MZ, Thakker RV, Yildiz BO, Clarke B. European Journal of Endocrinology (2019) 180, P1–P23
3. Hypophosphatasia: Canadian Update on diagnosis and management. AA Khan, R. Josse, P. Kannu, J. Villeneuve, T. Paul, S.Van Uum, C.R. Greenberg Osteoporosis International March 2019 30:1713–1722
4. Tools for Enhancement and Quality Improvement of Peer Assessment and Clinical Care in Endocrinology and Metabolism. by Aliya Khan, Anne Kenshole, Shereen Ezzat, Jeannette Goguen, Karen Gomez-Hernandez, Robert A. Hegele, Robyn Houlden, Tisha Joy, Erin Keely, Donald Killinger, André Lacroix, Sheila Laredo, Ally P.H. Prebtani, M. Z. Shrayyef, Chris Tran, Stan Van Uum, Rhoda Reardon, Antiope Papageorgiou, William Tays, and Merrill Edmonds Journal of Clinical Densitometry Sept 2017
5. Case-Based Review of Osteonecrosis of the Jaw (ONJ) and Application of the International Recommendations for Management From the International Task Force on ONJ Aliya A. Khan, Archie Morrison, David L. Kendler, Rene Rizzoli, David A. Hanley, Dieter Felsenberg, Laurie K. McCauley, Felice O’Ryan, Ian R. Reid, Salvatore L. Ruggiero, Akira Taguchi, Sotirios Tetradis, Nelson B. Watts, Maria Luisa Brandi, Edmund Peters, Teresa Guise, Richard Eastell, Angela M. Cheung, Suzanne N. Morin, Basel Masri, Cyrus Cooper, Sarah L. Morgan, Barbara Obermayer-Pietsch, Bente L. Langdahl, Rana Al Dabagh, K. Shawn Davison, George K. Sándor, Robert G. Josse, Mohit Bhandari, Mohamed El Rabbany, Dominique D. Pierroz, Riad Sulimani, Deborah P. Saunders, Jacques P. Brown Juliet Compston on behalf of the International Task Force on Osteonecrosis of the Jaw Journal of Clinical Densitometry Jan 2017
6. Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and International Consensus. Aliya A. Khan, David A. Hanley, Rene Rizzoli, Jens Bollerslev, J.E.M Young, Lars Rejnmark, Rajesh Thakker, Pierre D’Amour, Terri Paul, Stan Van Uum, M. Zakarea Shrayyef, David Goltzman, Stephanie Kaiser, Natalie E. Cusano, Roger Bouillon, Leif Mosekilde, Annie W. Kung, Sudhaker D. Rao, Sanjay K. Bhadada, Bart L. Clarke, Jian-min Liu, Quan-Yang Duh, E. Michael Lewiecki, Francisco Bandeira, Richard Eastell, Claudio Marcocci, Shonni J. Silverberg, Robert Udelsman, K. Shawn Davison, John T. Potts Jr, Maria Luisa Brandi, and John P. Bilezikian,  Osteoporos Int (2017) 28:1–19
7. Management of Hypoparathyroidism: Summary Statement and Guidelines, Maria Luisa Brandi, John P. Bilezikian, Dolores Shoback, Roger Bouillon, Bart Clarke, Rajesh V. Thakker, Aliya Khan, and John T. Potts Jr, JCEM Epub 2016 Mar, DOI: 10.1210/jc.2015-3907
8. Practice| Five things to know about Atypical Femoral Fractures Aliya Aziz Khan MD, Stephanie Kaiser MD CMAJ 2017 April 10;
9. Atypical Femoral Fracture Alert Program, Aliya A. Khan, Sian Iles, Stephanie M. Kaiser, Linda Probyn, Angela Cheung, Steven Burrell, Canadian Association of Radiologists Journal 2016 Jun; 20:1-2. DOI:10.1016/j.carj.2016.04.002
10. Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery, Aliya Aziz Khan,John Bilezikian, Henry G Bone, Andrey Gurevich, Péter Lakatos, Waldemar Misiorowski, Liudmila Rozhinskaya, Marie-Louise Trotman and Miklos Toth, European Journal of Endocrinology 2015 May;172(5):527-35. doi: 10.1530/EJE-14-0877. Epub 2015 Jan 30
11. Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus, Khan A, Morrison A, Hanley D, Felsenberg D, McCauley L, O’Ryan F, Reid I, Rugglero S, Taguchi A, Tetradis S, Watts N, Brandi M, Peters E, Guise T, Eastell R, Cheung A, Morin S, Masri B, Cooper C, Morgan S, Obermayer-Pietsch B, Langdahl B, Al Dabagh R, Davison K, Kendler D, Sandor G, Josse R, Bhandari M, El Rabbamy M, Plerroz D, Sulimani R, Saunders D, Brown J, Compston J, J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405
12. A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Alendronate on Bone Mineral Density and Bone Remodelling in Perimenopausal Women With Low Bone Mineral Density, Khan A, Fortier M, Menopause and Osteoporosis Working Group, Fortier M, Reid R, Abramson BL, Blake J, Desindes S, Dodin S, Graves L, Guthrie B, Johnston S, Khan A, Rowe T, Sodhi N, Wilks P, Wolfman N., J Obstet Gynaecol Can., 2014 Nov 36(11):976-982.
13. Osteoporosis in Menopause, Khan A, Fortier M, Menopause and Osteoporosis Working Group, Fortier M, Reid R, Abramson BL, Blake J, Desindes S, Dodin S, Graves L, Guthrie B, Johnston S, Khan A, Rowe T, Sodhi N, Wilks P, Wolfman N., J Obstet Gynaecol Can. 2014 Sep;36(9):839-840.
14. Atypical Femoral Fractures: A Teaching Perspective, Aliya A. Khan, William D. Leslie, Brian Lentle, Sian Iles, Stephanie M. Kaiser, Heather Frame, Steven Burrell, Angela M. Cheung, Can Assoc Radiol J., 2015 May;66(2):102-7. doi: 10.1016/j.carj.2014.01.002.Epub 2014 Jul 19
15. Hypoparathyroidism: Current therapies for management – A Clinical Review, Hafsah Al- Azem and Aliya Khan, Best Practice and Research Clinical Endocrinology and Metabolism, 2012 Aug, 26(4):517-537
16. Hyperparathyroidism – Diagnosis and Management – a Clinical Review, Shelley Pallan, Omair Rahman, Aliya Khan, British Medical Journal, 2012 Mar; 344:e1013
17. Official Positions for FRAX® Bone Mineral Density and FRAX® simplification from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®,E. Michael Lewiecki, Juliet E. Compston, Paul D. Miller, Jonathon D. Adachi, Judith E. Adams, William D. Leslie, John A. Kanis, Alireza Moayyeri, Robert A. Adler, Didier B. Hans, David L. Kendler, Adolfo Diez-Perez, Marc-Antoine Kireg, Basel K. Masri, Roman R. Lorenc, Douglas C. Bauer, Glen M. Blake, Robert G. Josse, Patricia Clark, Aliya A. Khan, The International Society for Clinical Densitometry, Journal of Clinical Densitometry: Assessment of Skeletal Health, 2011;14(3):226-236
18. Hypoparathyroidism in the Adult: Epidemiology, Diagnosis, Pathophysiology, Target-Organ Involvement, Treatment, and Challengers for Future Research, John P. Bilezikian, Aliya Khan, John T. Potts Jr., Maria Luisa Brandi, Bart L. Clarke, Dolores Shoback, Harald Juppner, Pierre D’Amour, John Fox, Lars Rejnmark, Leif Mosekilde, Mishaela R. Rubin,David Dempster, Rachel Gafni, Michael T. Collins, Jim Sliney, and James Sanders, JBMR 2011 Oct;26(10):2317-37. doi: 10.1002/jbmr.483
19. Primary Hyperparathyroidism, Hafsah Al-Azem, Aliya Khan, CMAJ, 2011 Jul 12;183(10):E685-9. doi: 10.1503/cmaj.090675. Epub 2011 Apr 26
20. Bisphosphonate-associated Osteonecrosis of the Jaw in Ontario: A Survey of Oral and Maxillofacial Surgeons, Aliya A. Khan, Lorena P. Rios, George K.B. Sandor, Nazir Khan,Edmund Peters, Mohammed O. Rahman, Cameron M.L. Clokie, Edward Dore and Sacha Dubois, Journal of Rheumatology, 2011 Jul;38(7):1396-402. doi: 10.3899/jrheum.100221. Epub 2011 Apr 15.Management of Hypoparathyroidism: Summary Statement and Guidelines, Maria Luisa Brandi, John P. Bilezikian, Dolores Shoback, Roger Bouillon, Bart Clarke, Rajesh V. Thakker, Aliya Khan, and John T. Potts Jr, JCEM Epub 2016 Mar, DOI: 10.1210/jc.2015-390
21. Standards and Guidelines for Technologists Performing Central Dual-Energy X-Ray Absorptiometry by Aliya A. Khan, Anita Colquhoun, David A. Hanley Lawrence G. Jankowski, Robert G. Josse, , David L. Kendler, Brian Lentle, William D. Leslie, E. Michael Lewiecki, Elaine O’Neill, Stephen Robertson, Zeba A. Syed, S. Bobo Tanner and Dave Webster JCD, Vol.10, no.2, 189-195, 2007
22. Management of Osteoporosis in men: an update and case example” Aliya A. Khan, Anthony B. Hodsman, Alexandra Papaioannou, David Kendler, Jacques P.  Brown, Wojciech P. OlszynksiCanadian Medical Association Journal, January 2007, 176(3), pp 345-348
23. Standards for Performing DXA in Individuals with Secondary Causes of Osteoporosis from the Canadian Panel of International Society for Clinical DensitometryA.A. Khan, D.A. Hanley, J.P. Bilezikian, N. Binkley, J.P. Brown, A.B. Hodsman, R.G. Josse D.L Kendler, E.M. Lewiecki, P.D. Miller, W.P. Olszynski, S.M. Petak, Z.A Syed, D Theriault, N.B. Watts.JCD, Vol. 9, no. 1, 47-57, 2006
24. “Management of Low Bone Mineral Density in Premenopausal Women” by Aliya Khan JOGC, April 2005, pp 345-349
25. Alendronate in Primary Hyperparathyroidism: A Double-Blind, Randomized,Placebo-  Controlled Trial Khan AA, Bilezikian JP, Kung AWC, Ahmed MM, Dubois SJ, Ho AYY, Schussheim D,     Rubin MR, Shaikh AM, Silverberg SJ, Standish TI, Syed Z, Syed ZA, J Clin Endocrinol Metab, July 2004, 89(7):3319-3325.
26. . Position Statement: The Writing Group for the ISCD Position Development Conference by the Writing Group” (Aliya Khan) Diagnosis of osteoporosis in men, premenopausal women and children, JCD     Vol. 7, #1, 13-15, 2004.
27. Standards and Guidelines for Performing Central Dual X-Ray Densitometry in Premenopausal Women, Men, and Children from the Canadian Panel of the International Society of Clinical Densitometry” Khan AA, Bachrach L, Brown JP, Hanley DA, Josse RG, Kendler DL, Leib ES, Lentle BC, Leslie WD, Lewiecki M, Miller PD, Nicholson RL, O’Brien C, Olszynski WP, Theriault MYD, Watts NB, JCD, Vol. 7, no. 1, 51-63, 2004.
28. Position Paper:  Asymptomatic Primary Hyperparathyroidism – Standards and Guidelines for Diagnosis and Management in Canada Khan AA, Hanley DA, O’Brien CJ, Pasieka J, Ste-Marie LG, Rotstein LE, Rosen I, Young JEM, Josse RG, Bilezikian JP Endocrine Practice Vol. 9 No. 5 September/October 2003 pp 400-405.
29. Standards and Guidelines for Performing Central Dual X-Ray Densitometry from      the Canadian Panel of             International Society for Clinical Densitometry By: Khan AA, Brown J, Faulkner K, Kendler D, Lentle B, Leslie W, Miller PD, Nicholson L, Olszynski WP and Watts NB, Journal of Clinical Densitometry Vol. 5, No. 4, 435-445, Winter 2002
30. Standards and Guidelines for Performing Central Dual X-Ray Densitometry from the Canadian Panel of International Society for Clinical Densitometry By:  Khan AA, Brown J, Faulkner K, Kendler D, Lentle B, Leslie W, Miller P, Nicholson L, Olszynski WP, Watts NB Journal of Clinical Densitometry Vol 5. No. 3, 247-257, Fall 2002.
31. The 2002 Canadian Bone Densitometry Recommendations: Take-home Messages By:Khan AA, Brown JP, Kendler DL, Leslie WD, Lentle BC, Lewiecki M, Miller PD, Nicholson RL, Olszynski WP, Watts NBCMAJ November 12, 2002; 167(10), 1141-1145.

• (2019) Hypoparathyroidism in pregnancy: review and evidence-based recommendations for management 
• (2018) MedicalHypoparathyroidism
• (2017) Atypical femoral fracture
• (2017) Hyperparathyroidism Sept 2017
• (2017) Case-Based Review of Osteonecrosis of the Jaw (ONJ) and Application of the International Recommendations for Management From the International Task Force on ONJ
• (2017) Drug-Related Adverse Events of Osteoporosis Therapy
• (2017) Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A    Canadian and International Consensus, 
• (2017) Quality Improvement Resources For Endocrinology and Metabolism, Endorsed by The Canadian Society of Endocrinology and Metabolism (CSEM) 
• (2017) Hypercalcemia
• (2016) Atypical Femoral Fracture Alert Program
• (2016) Primary hyperparathyroidism
• (2016) Presentation of Hypoparathyroidism: Etiologies and Clinical Features
• (2016) Management of Hypoparathyroidism: Summary Statement and Guidelines
• (2015) Osteonecrosis of the Jaw (ONJ) diagnosis and management in 2015
• (2015) Update for dentists: Osteonecrosis of the jaw- CDA Oasis
• (2015) Bilateral atypical femoral fractures: how much symmetry is there on imaging?
• (2015) Persistance with denosumab therapy among osteoporotic women in the Canadian patient support program Alexandra Papaioannou
• (2015) Response to Comments on “Diagnosis and Management of Osteoporosis of the Jaw: A Systematic Review and International Consensus”
• (2015) Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery
• (2014) Fracture Risk Assessment and EpidemiologyDevelopment of Recommendations for Radiologists Regarding the Evaluation and Management of Osteoporosis When Reporting Major Osteoporotic Fractures in Those Over Age 50
• (2014) Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus
• (2014) Managing Menopause
• (2014) Osteoporosis in Menopause
• (2014) A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Alendronate on Bone Mineral Density and Bone Remodelling in Perimenopausal Women With Low Bone Mineral Density
• (2014) Foundation for Medical Practice Education “Calcium levels when to test and how to handle abnormal results”
• (2014) Medical Management of Primary Hyperparathyroidism of the Fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism
• (2014) Atypical Femoral Fractures: Radiographic Histomorphometric Features in 19 Patients
• (2014) Atypical Femoral Fractures: A Teaching Perspective
• (2014) “Bisphosphonates for Treatment of Osteoporosis” (Clinical Review)
• (2013) Denosumab, a New Pharmacotherapy Option for Postmenopausal Osteoporosis
• (2013) Improving Management of Osteoporosis Through Simple Changes in Reporting Fragility Fractures
• (2013) Medical Management of Primary Hyperparathyroidism
• (2013) Supplement on Primary Hyperparathyroidism – Editorial
• (2013) Denosumab, a new pharmacotherapy option for postmenopausal osteoporosis
• (2012) Atypical Femoral Fractures – What you need to know
• (2012) Evaluation and Management of Celiac Disease in Osteoporosis: Position Statement
• (2012) Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement
• (2012) Hypoparathyroidism : Current therapies for management – A Clinical Review
• (2012) Hyperparathyroidism – Diagnosis and Management – a Clinical Review
• (2012) Hypoparathyroidism – Clinical Diagnosis and Management for the primary care physician
• (2011) Official Positions for FRAX® Bone Mineral Density and FRAX® simplification from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®
• (2011) Hypoparathyroidism in the Adult: Epidemiology, Diagnosis, Pathophysiology, Target-Organ Involvement, Treatment, and Challengers for Future Research
• (2011) FRAX Bone Mineral Density Task Force of the 2010 Joint International Society for Clinical Densitometry and International Osteoporosis Foundation Position Development Conference
• (2011) Bisphosphonate-associated Osteonecrosis of the Jaw in Ontario: A Survey of Oral and Maxillofacial Surgeons
• (2011) Primary Hyperparathyroidism
• (2011) Primary hyperparathyroidism: Update on presentation, diagnosis, and management in primary care
• (2010) Asymptomatic Primary Hyperparathyroidism – Commentary on Current Management
• (2010) Osteonecrosis of the jaw and bisphosphonates
• (2009) Alendronate Therapy in Men with Primary Hyperparathyroidism
• (2009) Asymptomatic PHPT: A commentary on the revised guidelines
• (2009) Risk factors for low BMD in healthy men age 50 years or older: a systematic review
• (2009) Bisphosphonate associated osteonecrosis of the jaw
• (2009) Menopause and osteoporosis
• (2009) Osteonecrosis of the jaw
• (2009) Medical Management of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
• (2009) Workshop on the Management of Asymptomatic Primary Hyperthyroidism SUMMARY STATEMENT: Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Third International Workshop
• (2009) Guest Editors for the Third International Workshop on Asymptomatic Primary Hyperparathyroidism EDITORIAL: The Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism Revisited
• (2008) Osteonecrosis of the jaw: new developments in an old disease
• (2008) Osteoporosis Screening and Assessment of Fracture Risk
• (2008) Canadian Consensus Practice Guidelines for Bisphosphonate Associated Osteonecrosis of the Jaw
• (2008) Raloxifene and the Perimenopause
• (2008) Osteoporosis Osteonecrosis of the jaw: Summary and perspective
• (2008) Risk factors for low BMD in healthy men age 50 years or older: a systematic review
• (2008) Osteonecrosis of the Jaw- relationship to bisphosphonate use: commentary and perspective
• (2008) Dual-Energy X-Ray Absorptiometry Technical Issues: The 2007 ISCD Official Positions
• (2008) Canadian Consensus Practice Guidelines for Bisphosphonate Associated Osteonecrosis of the Jaw
• (2008) Osteonecrosis of the Jaw: New Developments in an Old Disease
• (2008) Cancer treatment—related bone loss: a review and synthesis of the literature
• (2007) Recommendations for Bone Mineral Density Reporting in Canada: A Shift to Absolute Fracture Risk Assessment
• (2007) Hyperparathyroidism: High calcium and PTH raise suspicions
• (2007) Middle East and North Africa consensus on osteoporosis
• (2007) Standards and Guidelines for Technologists Performing Central Dual-Energy X-Ray Absorptiometry
• (2007) Recognizing and Reporting Vertebral Fractures: Reducing the Risk of Future Osteoporotic Fractures
• (2007) Management of Osteoporosis in men: an update and case example
• (2006) Drug Therapy for Postmenopausal Osteoporosis: A Review
• (2006) Premenopausal Women and Low Bone Density
• (2006) Alendronate in Primary Hyperparathyroidism: Efficacy in Men and Premenopausal Women
• (2006) Standards for Performing DXA in Individuals with Secondary Causes of Osteoporosis from the Canadian Panel of International Society for Clinical Densitometry
• (2006) Bone Mineral Density Assessment in Premenopausal Women
• (2006) Anabolic Agents: A New Chapter in the Management of Osteoporosis
• (2005) Recommendations for bone mineral density reporting in Canada
• (2005) Management of Low Bone Mineral Density in Premenopausal Women
• (2005) Prevalence of Vitamin D Inadequacy Among Postmenopausal North American Women Receiving Osteoporosis Therapy
• (2004) Vitamin D Inadequacy is Highly Prevalent Among North American Women Treated for Osteoporosis
• (2004) Alendronate in Primary Hyperparathyroidism: A Double-Blind, Randomized, Placebo-Controlled Trial
• (2004) Bisphosphonates in osteoporosis; Ask the Expert
• (2004) Position Statement: The Writing Group for the ISCD Position Development Conference by the Writing Group
• (2004) Bone Densitometry in Premenopausal Women
• (2004) Standards and Guidelines for Performing Central Dual X-Ray Densitometry in Premenopausal Women, Men, and Children from the Canadian Panel of the International Society of Clinical Densitometry
• (2003) Statistics Can Affect Treatment Decisions
• (2003) Position Paper: Asymptomatic Primary Hyperparathyroidism – Standards and Guidelines for Diagnosis and Management in Canada
• (2003) A Double Blind Randomized Placebo Controlled Trial of Alendronate in Primary Hyperparathyroidism Plenary Poster Presentation
• (2003) What about bisphosphonates for a patient with hypertension and osteoporosis?
• (2003) Peak Performance; New Guidelines Set Standard for BMD Measurement Osteoporosis Update, official journal of the Osteoporosis Society of Canada
• (2003) Advances in Osteoporosis Therapy: 2003 Update of Practical Guidelines
• (2002) Standards and Guidelines for Performing Central Dual X-Ray Densitometry from the Canadian Panel of International Society for Clinical Densitometry
• (2002) 2002 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada
• (2002) The 2002 Canadian Bone Densitometry Recommendations: Take-home Messages
• (2002) A Double-Blind Randomized Placebo-Controlled Trial of Alendronate in Primary Hyperparathyroidism
• (2002) Bone Densitometry: Applications and Limitations
• (2001) Alendronate in Primary Hyperparathyroidism
• (2001) A Double-Blind Randomized Placebo-Controlled Trial of Alendronate in Primary Hyperparathyroidism
• (2001) Canadian Consensus on Menopause and Osteoporosis
• (2001) An Evidence-Based Review of the Management of Osteoporosis
• (2000) Advances in the Prevention of Post-menopausal Osteoporosis
• (2000) Skeletal Effects of Primary Hyperparathyroidism
• (2000) The Healthy Woman – Advances in Osteoporosis Research
• (2000) Primary Hyperparathyroidism – Pathophysiology and Impact on Bone
• (1998) Use of Cyclical Etidronate and the Prevention of Non-Vertebral Fractures
• (1997) Diagnosis and Management of Primary Hyperparathyroidism
• (1995) Osteoporosis associated with Pregnancy – Case Report and Review